Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 20/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 20/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 20/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 20/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871979 | 0.89 | PDK1 (0.51) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871763 | 0.88 | PDK1 (0.44) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871831 | 0.87 | PDK1 (0.49) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871982 | 0.86 | PDK1 (0.55) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL20429116 | 0.83 | PDK1 (0.51) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871843 | 0.81 | PDK1 (0.47) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871781 | 0.80 | PDK1 (0.47) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871839 | 0.79 | HRH3 (0.55) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6134120 | 0.76 | NPC1 (0.46) | — | |
| SCHEMBL20420837 | 0.75 | BRD4 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |