Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 18/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 18/20 | 0.55 |
| ▸ | PDK3 | Q15120 | 18/20 | 0.55 |
| ▸ | PDK4 | Q16654 | 18/20 | 0.55 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18871979 | 0.89 | PDK1 (0.51) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL20429116 | 0.89 | PDK1 (0.51) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871762 | 0.86 | PDK1 (0.49) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL26071793 | 0.85 | PDK1 (0.54) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL14756207 | 0.85 | PDK1 (0.54) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL18871839 | 0.84 | HRH3 (0.55) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871843 | 0.84 | PDK1 (0.47) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL18871781 | 0.83 | PDK1 (0.47) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL30366656 | 0.82 | BRD4 (0.53) | PDK1PDK2PDK3PDK4BRD4 | |
| SCHEMBL18871772 | 0.81 | CYP11B2 (0.54) | P4HA1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3168213-B1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3168213-A1 | TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS BROMODOMAIN INHIBITORS | Glaxosmithkline LLC (US) | 2017-05-17 | — | — | EP | disclosed |