Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | DAO | P14920 | 2/20 | 0.62 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 5/20 | 0.59 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.59 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | PPARA | Q07869 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894364 | 0.98 | HDAC1 (0.64) | TSHRDAONAPRTHDAC1TP53 | |
| SCHEMBL1926270 | 0.98 | HDAC1 (0.64) | TSHRDAONAPRTHDAC1TP53 | |
| Hydrochloric Acid SCHEMBL7704996 | 0.95 | HDAC1 (0.62) | TSHRDAONAPRTHDAC1TP53 | |
| Benzoic Acid SCHEMBL4779307 | 0.95 | DAO (0.70) | TSHRDAONAPRTHDAC1TP53 | |
| Paraben SCHEMBL9244762 | 0.91 | CA12 (0.67) | TSHRDAONAPRTHDAC1SRD5A2 | |
| Terephthalic Acid SCHEMBL4612225 | 0.90 | TSHR (0.67) | TSHRDAONAPRTHDAC1TP53 | |
| SCHEMBL70166 | 0.90 | TSHR (0.67) | TSHRDAONAPRTHDAC1TP53 | |
| SCHEMBL6260082 | 0.89 | TSHR (0.58) | TSHRDAONAPRTHDAC1SRD5A2 | |
| SCHEMBL1980515 | 0.89 | RARB (0.65) | HDAC1ALDH1A1 | |
| SCHEMBL1982703 | 0.89 | HDAC8 (0.67) | TSHRDAONAPRTHDAC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935656-B2 | Thermosensitive recording media and methods of making and using the same | NASHUA CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-20080015107-A1 | Thermosensitive recording media and methods of making and using the same | CENVEO WORLDWIDE LIMITED | 2008-01-17 | — | — | US | disclosed |
| WO-2008008509-A2 | THERMOSENSITIVE RECORDING COMPOSITIONS AND MEDIA AND METHODS OF USE THEREOF | NASHUA CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| EP-0987122-B1 | THERMAL RECORDING MATERIAL | ASAHI DENKA KOGYO KK (JP) | 2004-08-04 | — | — | EP | disclosed |
| EP-1060904-B1 | A thermally sensitive recording medium | JUJO PAPER CO LTD (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6583086-B1 | Good image preservability of recorded part, good resistance to humid and heat resistance | NIPPON PAPER INDUSTRIES CO. LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-6432875-B1 | LOW MOLECULAR WEIGHT POLYESTER | ASAHI DENKA KOGYO K.K. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1060904-A2 | A thermally sensitive recording medium | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 2000-12-20 | — | — | EP | disclosed |
| EP-0987122-A1 | THERMAL RECORDING MATERIAL | ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) | 2000-03-22 | — | — | EP | disclosed |
| EP-0366461-B1 | Optical recording medium | JUJO PAPER CO LTD (JP) | 1997-02-19 | — | — | EP | disclosed |
| US-5075146-A | Containing heat sensitive color developable layer on infrared absorbent substrates | JUJO PAPER CO., LTD. (JP) | 1991-12-24 | — | — | US | disclosed |
| EP-0366461-A2 | Optical recording medium | NIPPON PAPER INDUSTRIES CO., LTD. (JP) | 1990-05-02 | — | — | EP | disclosed |
| US-4503446-A | DIBENZYL TEREPHTHALATE OR ISOPHTHALATE AS SENSITIZER | SHIN NISSO KAKO CO., LTD. (JP) | 1985-03-05 | — | — | US | disclosed |