SCHEMBL8894364

SCHEMBL8894364

O=C(O)c1ccc(CCc2ccc(CCc3ccccc3)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.64
FFAR1 O14842 1/20 0.61
PPARA Q07869 1/20 0.61
TSHR P16473 3/20 0.59
DAO P14920 2/20 0.59
NAPRT Q6XQN6 1/20 0.59
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.57
SRD5A2 P31213 4/20 0.57
NR4A1 P22736 1/20 0.57
NR4A2 P43354 1/20 0.57
NR4A3 Q92570 1/20 0.57
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
HDAC8 Q9BY41 1/20 0.55
RARB P10826 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1926270 1.00 HDAC1 (0.64) HDAC1FFAR1PPARATSHRDAO
Hydrochloric Acid SCHEMBL7704996 0.98 HDAC1 (0.62) HDAC1FFAR1PPARATSHRDAO
Terephthalic Acid SCHEMBL1887306 0.98 TSHR (0.62) HDAC1FFAR1PPARATSHRDAO
Benzoic Acid SCHEMBL4779307 0.93 DAO (0.70) HDAC1FFAR1PPARATSHRDAO
Terephthalic Acid SCHEMBL4612225 0.93 TSHR (0.67) HDAC1PPARATSHRDAONAPRT
SCHEMBL70166 0.93 TSHR (0.67) HDAC1PPARATSHRDAONAPRT
SCHEMBL6260082 0.92 TSHR (0.58) HDAC1FFAR1PPARATSHRDAO
SCHEMBL1980515 0.91 RARB (0.65) HDAC1ALDH1A1HDAC8RARB
SCHEMBL1982703 0.91 HDAC8 (0.67) HDAC1TSHRDAONAPRTALDH1A1
Hydrochloric Acid SCHEMBL7132238 0.90 TSHR (0.63) HDAC1PPARATSHRDAONAPRT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629288-A BACTERICIDE HOECHST AKTIENGESELLSCHAFT (DE) 1997-05-13 US disclosed