Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18873931 | 0.92 | LPAR1 (0.53) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL18874422 | 0.90 | LPAR1 (0.51) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL1560250 | 0.87 | LPAR1 (0.67) | LPAR1SIGMAR1NPC1RAB9AHDAC1 | |
| SCHEMBL18874414 | 0.86 | LPAR1 (0.51) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL18874049 | 0.85 | LPAR1 (0.55) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL18873929 | 0.84 | LPAR1 (0.55) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL18874305 | 0.83 | LPAR1 (0.51) | LPAR1SIGMAR1SIRT2NPC1RAB9A | |
| SCHEMBL18874390 | 0.83 | LPAR1 (0.51) | LPAR1POLBSIGMAR1SIRT2NPC1 | |
| SCHEMBL18873882 | 0.83 | LPAR1 (0.56) | LPAR1SIGMAR1SIRT2C5AR1 | |
| SCHEMBL18874036 | 0.83 | LPAR1 (0.56) | LPAR1POLBSIRT2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303270-B1 | ACYLAMINO-SUBSTITUTED FUSED CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2017-05-17 | — | — | EP | disclosed |