Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 8/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18875031 | 1.00 | PNMT (0.54) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL8258918 | 0.82 | PNMT (0.55) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL25208667 | 0.81 | PNMT (0.51) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL30412091 | 0.81 | PNMT (0.51) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL417912 | 0.81 | MAPT (0.60) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL13875069 | 0.81 | PNMT (0.54) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL29557821 | 0.81 | MAPT (0.60) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL24040085 | 0.81 | PNMT (0.54) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL24869958 | 0.81 | PNMT (0.54) | PNMTADRA2AHTR2AHTR2CHTR2B | |
| SCHEMBL31335752 | 0.81 | MAPT (0.60) | PNMTADRA2AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | GLENMARK SPECIALITY S.A. (CH) | 2023-07-20 | — | — | US | disclosed |
| US-20170145007-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVE AND ANTICANCER PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145007-A1 | PYRIMIDINE-2,4-DIAMINE DERIVATIVE AND ANTICANCER PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT | ALK, NPM1, ETV6 | PNMT 1417/4885ADRA2A 4724/4885HTR2A 4720/4885 |
| US-20230227483-A1 | PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS | MAP4K1, MAP3K4, MAP4K2 | PNMT 2911/4885ADRA2A 4209/4885HTR2A 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.