Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3150994 | 0.88 | KDM4E (0.65) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL13512464 | 0.85 | KDM4E (0.59) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL803088 | 0.82 | KDM4E (0.59) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL29263688 | 0.82 | KDM4E (0.61) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL13512585 | 0.82 | KDM4E (0.61) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL3150985 | 0.82 | KDM4E (0.65) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL17266314 | 0.81 | KDM4E (0.64) | KDM4ESMN1; SMN2L3MBTL1ALDH1A1TRPV6 | |
| SCHEMBL3936986 | 0.80 | KDM4E (0.63) | KDM4ESMN1; SMN2L3MBTL1CYP2C19POLB | |
| SCHEMBL30141847 | 0.79 | CYP1A2 (0.71) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 | |
| SCHEMBL20804356 | 0.79 | CYP1A2 (0.71) | KDM4ESMN1; SMN2L3MBTL1CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | HNMT, TYR, PNMT | KDM4E 418/4885SMN1; SMN2 4397/4885L3MBTL1 1402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.