Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20272449 | 0.80 | KDM4E (0.49) | KDM4EMAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL18878966 | 0.76 | ALDH1A1 (0.43) | KDM4EMAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL18120562 | 0.64 | ALDH1A1 (0.40) | KDM4EMAPK1MAPTENPP1ALDH1A1 | |
| SCHEMBL23143345 | 0.64 | SMN1; SMN2 (0.36) | KDM4EMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2323756 | 0.63 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL5316044 | 0.61 | EGLN2 (0.45) | KDM4EMAPK1MAPTENPP1ALDH1A1 | |
| SCHEMBL14506996 | 0.61 | KDM4E (0.52) | KDM4EMAPK1MAPTENPP1ALDH1A1 | |
| SCHEMBL7096531 | 0.60 | ALDH1A1 (0.48) | KDM4EMAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL11476738 | 0.60 | ALDH1A1 (0.74) | KDM4EMAPK1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL868954 | 0.59 | KDM4E (0.49) | KDM4EMAPK1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | EFFECTOR THERAPEUTICS, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | MAP3K9, MAP3K19, MAP3K20 | KDM4E 1316/4885MAPK1 166/4885MAPT 2303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.