Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194731 | 0.79 | TAAR1 (0.58) | TAAR1HRH3HRH4 | |
| SCHEMBL17383815 | 0.77 | HRH3 (0.60) | HRH3HRH4 | |
| SCHEMBL224745 | 0.77 | TAAR1 (1.00) | TAAR1HRH3HRH4 | |
| SCHEMBL1239352 | 0.75 | HRH3 (0.76) | HRH3HRH4 | |
| SCHEMBL8402960 | 0.74 | SIGMAR1 (0.71) | TAAR1 | |
| SCHEMBL2536900 | 0.74 | HRH3 (0.93) | TAAR1HRH3HRH4 | |
| SCHEMBL22894772 | 0.73 | HRH3 (0.48) | TAAR1HRH3HRH4 | |
| SCHEMBL5349780 | 0.73 | CHRNA7 (0.67) | — | |
| SCHEMBL631711 | 0.72 | TAAR1 (1.00) | TAAR1HRH3 | |
| SCHEMBL7055109 | 0.72 | CARM1 (0.75) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495365-A1 | P2X7 MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |
| EP-3239151-A1 | P2X7 MODULATORS | Janssen Pharmaceutica NV (BE) | 2017-11-01 | — | — | EP | disclosed |
| EP-2970267-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-24 | — | — | EP | disclosed |