Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 9/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 9/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | RBP4 | P02753 | 9/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31496063 | 0.88 | MAPK1 (0.56) | MAPK1EP300CREBBPBRD4 | |
| SCHEMBL17317850 | 0.86 | P2RX7 (0.39) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL16127191 | 0.84 | CREBBP (0.52) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL17232648 | 0.83 | EP300 (0.49) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL24157629 | 0.81 | MAPK1 (0.53) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL17317597 | 0.80 | ADORA1 (0.44) | MAPK1RBP4 | |
| SCHEMBL17229622 | 0.79 | MAPK1 (0.48) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL19831854 | 0.79 | MAPK1 (0.45) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL17234808 | 0.79 | EP300 (0.49) | MAPK1EP300CREBBPBRD4RBP4 | |
| SCHEMBL14970433 | 0.78 | RBP4 (0.53) | MAPK1EP300CREBBPBRD4RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495365-A1 | P2X7 MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |
| EP-3239151-A1 | P2X7 MODULATORS | Janssen Pharmaceutica NV (BE) | 2017-11-01 | — | — | EP | disclosed |
| EP-2970267-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-24 | — | — | EP | disclosed |