Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19261447 | 0.76 | — | — | |
| SCHEMBL24699515 | 0.70 | — | — | |
| SCHEMBL7459354 | 0.69 | — | — | |
| SCHEMBL23346814 | 0.67 | — | — | |
| SCHEMBL10686440 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL22342374 | 0.65 | ALDH1A1 (0.39) | ALDH1A1NPSR1TDP1GAAPOLB | |
| SCHEMBL20374229 | 0.64 | ALDH1A1 (0.38) | ALDH1A1NPSR1TDP1GAAPOLB | |
| SCHEMBL20669715 | 0.62 | TSHR (0.46) | TSHR | |
| SCHEMBL22380663 | 0.60 | TSHR (0.64) | ALDH1A1NPSR1GAAMAPTKDM4E | |
| SCHEMBL99049 | 0.60 | TSHR (0.64) | ALDH1A1NPSR1GAAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10822377-B2 | Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200031872-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | 2020-01-30 | — | — | US | disclosed |
| US-20170143731-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | ZENITH EPIGENETICS LTD. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143731-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | BRD4, BRDT, BRD3 | ALDH1A1 4346/4885NPSR1 4518/4885TDP1 904/4885 |
| US-10822377-B2 | Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase | CLPP, DNPEP, PEPD | ALDH1A1 4416/4885NPSR1 2107/4885TDP1 1464/4885 |
| US-20200031872-A1 | Substituted Urea Depsipeptide Analogs as Activators of the CLPP Endopeptidase | CLPP, DNPEP, PEPD | ALDH1A1 4416/4885NPSR1 2107/4885TDP1 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.