Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.68 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.51 |
| ▸ | FEN1 | P39748 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244614 | 0.81 | ABL1 (1.00) | ABL1KDRLCK | |
| SCHEMBL9939085 | 0.81 | ABL1 (0.78) | ABL1KDRLCK | |
| SCHEMBL5497661 | 0.76 | ABL1 (0.71) | ABL1KDRLCK | |
| SCHEMBL4143337 | 0.74 | GAA (0.45) | ABL1ALOX5APFEN1KDRGAA | |
| SCHEMBL15559049 | 0.70 | CRHR1 (0.49) | GAA | |
| SCHEMBL10288466 | 0.69 | ABL1 (1.00) | ABL1 | |
| SCHEMBL15629998 | 0.69 | ABL1 (0.74) | ABL1KDRLCK | |
| SCHEMBL18190616 | 0.68 | SMYD3 (0.50) | KDRGAA | |
| SCHEMBL14244867 | 0.68 | ABL1 (0.69) | ABL1ALOX5APFEN1KDRLCK | |
| SCHEMBL18887341 | 0.67 | MEN1 (0.58) | ABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651899-B1 | SUBSTITUTED 6,6-FUSED NITROGENOUS HETEROCYCLIC COMPOUNDS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2017-05-31 | — | — | EP | disclosed |