Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15559049 | 0.81 | CRHR1 (0.49) | GAAKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL4005323 | 0.75 | MAPK14 (0.66) | KDR | |
| SCHEMBL18190616 | 0.74 | SMYD3 (0.50) | GAAKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL18887343 | 0.74 | ABL1 (0.68) | GAAALOX5APFEN1ABL1KDR | |
| SCHEMBL1987660 | 0.73 | TAS1R3 (0.64) | GAAKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL28536621 | 0.72 | PPARG (0.42) | GAAALOX5APKMT2AALDH1A1MEN1 | |
| SCHEMBL960202 | 0.72 | RAB9A (0.50) | KMT2AMEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1233190 | 0.72 | MEN1 (0.47) | KMT2AMEN1LMNANPC1RAB9A | |
| SCHEMBL3172457 | 0.71 | TAS1R3 (0.59) | GAAKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL738587 | 0.71 | P2RX7 (0.71) | GAAKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009078992-A1 | LINEAR TRICYCLIC COMPOUNDS AS P38 KINASE INHIBITORS | AMGEN INC. (US) | 2009-06-25 | — | — | WO | disclosed |