SCHEMBL1889009

SCHEMBL1889009

COc1ccc(-c2ccc(-c3cccc(C)c3)c(C)c2)c(CCC(=O)O)c1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 13/20 0.54
FFAR4 Q5NUL3 4/20 0.54
POLB P06746 1/20 0.48
MTNR1A P48039 1/20 0.47
MTNR1B P49286 1/20 0.47
PTGER4 P35408 3/20 0.46
PTGER3 P43115 3/20 0.46
PTGER1 P34995 2/20 0.45
PTGER2 P43116 2/20 0.45
EGFR P00533 1/20 0.44
PDGFRB P09619 1/20 0.44
FGFR1 P11362 1/20 0.44
KDR P35968 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17254706 0.91 FFAR1 (0.54) FFAR1FFAR4POLBMTNR1AMTNR1B
SCHEMBL1886592 0.90 FFAR1 (0.53) FFAR1FFAR4POLBMTNR1AMTNR1B
SCHEMBL19257223 0.90 MTNR1A (0.49) FFAR1FFAR4MTNR1AMTNR1B
SCHEMBL35843152 0.89 FFAR1 (0.55) FFAR1FFAR4PTGER4PTGER3PTGER1
SCHEMBL1808327 0.89 FFAR1 (0.55) FFAR1FFAR4PTGER4PTGER3PTGER1
SCHEMBL1887137 0.89 FFAR1 (0.53) FFAR1FFAR4POLBMTNR1AMTNR1B
SCHEMBL12660792 0.88 POLB (0.52) FFAR1FFAR4POLBMTNR1AMTNR1B
SCHEMBL16605158 0.88 FFAR1 (0.54) FFAR1FFAR4PTGER4PTGER3PTGER1
SCHEMBL1892714 0.88 MTNR1A (0.47) FFAR1FFAR4MTNR1AMTNR1B
SCHEMBL35843127 0.88 MTNR1A (0.47) FFAR1FFAR4MTNR1AMTNR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3049815-B1 GOODPASTURE ANTIGEN BINDING PROTEIN DETECTION AND INHIBITION AND ITS USE IN DIABETES FIBROSTATIN SL (ES) 2019-03-13 EP claimed
US-20170204197-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes FIBROSTATIN S L (ES) 2017-07-20 US claimed
EP-3049815-A1 GOODPASTURE ANTIGEN BINDING PROTEIN DETECTION AND INHIBITION AND ITS USE IN DIABETES Fibrostatin, Sociedad Limitada (ES) 2016-08-03 EP claimed
US-20160184274-A1 Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition UNIVERSITAT DE VALENCIA (ES) 2016-06-30 US claimed
WO-2015044352-A1 GOODPASTURE ANTIGEN BINDING PROTEIN DETECTION AND INHIBITION AND ITS USE IN DIABETES FIBROSTATIN, S.L. (ES) 2015-04-02 WO claimed
US-20150093378-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes FIBROSTATIN, S.L. (ES) 2015-04-02 US claimed
EP-2496544-B1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN S L (SE) 2014-08-20 EP claimed
US-8586776-B2 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2013-11-19 US claimed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 US claimed
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics UNIVERSITAT DE VALÈNCIA (ES) 2020-01-28 US disclosed
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics UNIVERSITAT DE VALÈNCIA (ES) 2020-01-28 US disclosed
EP-3049815-B1 GOODPASTURE ANTIGEN BINDING PROTEIN DETECTION AND INHIBITION AND ITS USE IN DIABETES FIBROSTATIN SL (ES) 2019-03-13 EP disclosed
EP-3049815-B1 GOODPASTURE ANTIGEN BINDING PROTEIN DETECTION AND INHIBITION AND ITS USE IN DIABETES FIBROSTATIN SL (ES) 2019-03-13 EP disclosed
US-20180179139-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2018-06-28 US disclosed
US-8586776-B2 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2013-11-19 US disclosed
US-8586776-B2 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2013-11-19 US disclosed
WO-2011054530-A1 GPBP INHIBITION USING Q2 PEPTIDOMIMETICS FIBROSTATIN, S.L. (ES) 2011-05-12 WO disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 US disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 US disclosed
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics FIBROSTATIN, S.L. (ES) 2011-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204197-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes CD2BP2, SAP30BP, LY96 FFAR1 3034/4885FFAR4 2309/4885POLB 3109/4885
US-20150093378-A1 Goodpasture Antigen Binding Protein Detection and Inhibition and its Use in Diabetes CD2BP2, SAP30BP, LY96 FFAR1 3034/4885FFAR4 2309/4885POLB 3109/4885
US-10544083-B2 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 FFAR1 2951/4885FFAR4 2889/4885POLB 2317/4885
US-20110105545-A1 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 FFAR1 2951/4885FFAR4 2889/4885POLB 2317/4885
US-20160184274-A1 Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition VIM, EPCAM, CDH1 FFAR1 4443/4885FFAR4 4492/4885POLB 3902/4885
US-20180179139-A1 GPBP inhibition using Q2 peptidomimetics HSP90B1, ERP44, HSPA5 FFAR1 2951/4885FFAR4 2889/4885POLB 2317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.