Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380505 | 0.85 | CYP3A4 (0.51) | MEN1KMT2AMAPTKDM4EL3MBTL1 | |
| SCHEMBL16130131 | 0.74 | CHKA (0.60) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL9773708 | 0.73 | CYP3A4 (0.50) | MEN1KMT2AKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL64210 | 0.73 | CHKA (0.58) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL18890222 | 0.72 | KDM4E (0.64) | MEN1KMT2AMAPTATMKDM4E | |
| Hydrochloric Acid SCHEMBL10901938 | 0.72 | KDM4E (0.66) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL20333115 | 0.71 | CHKA (0.50) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL20333157 | 0.71 | MEN1 (0.60) | MEN1KMT2AMAPTATMKDM4E | |
| SCHEMBL15710575 | 0.70 | KDM4E (0.50) | MEN1KMT2AMAPTKDM4EL3MBTL1 | |
| SCHEMBL9831170 | 0.70 | KMT2A (0.59) | MEN1KMT2AMAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170823-B1 | 6,7-DIHYDRO-2H-PYRAZOLO[4,3-C]PYRIDIN-3(5H)-ONE DERIVATIVES AND THEIR USE FOR TREATING A DISEASE ASSOCIATED WITH AMPK KINASE ACTIVITY | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-04-28 | — | — | EP | disclosed |
| US-10196389-B2 | One class of pyrazolone compounds and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-02-05 | — | — | US | disclosed |
| US-20170247371-A1 | ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-31 | — | — | US | disclosed |
| US-20170247371-A1 | ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-08-31 | — | — | US | disclosed |
| EP-3170823-A1 | ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF | Shanghai Institute Of Materia Medica Chinese Academy of Sciences (CN) | 2017-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247371-A1 | ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF | PRKAA1, PCK2, GOT1 | MEN1 4146/4885KMT2A 4092/4885MAPT 1829/4885 |
| US-10196389-B2 | One class of pyrazolone compounds and use thereof | PRKAA1, PCK2, GOT1 | MEN1 4146/4885KMT2A 4092/4885MAPT 1829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.