SCHEMBL18891725

SCHEMBL18891725

Cc1ccc2cc(-c3ccc(Br)cc3)ccc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 4/20 0.56
CYP1A2 P05177 4/20 0.56
MAOB P27338 2/20 0.53
ALDH1A1 P00352 5/20 0.50
TDP1 Q9NUW8 1/20 0.48
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
KDM4E B2RXH2 2/20 0.41
MAPK1 P28482 2/20 0.41
APP P05067 1/20 0.41
PAX8 Q06710 1/20 0.41
ESR1 P03372 3/20 0.40
ESR2 Q92731 3/20 0.40
RAPGEF4 Q8WZA2 1/20 0.38
HPGD P15428 2/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19660697 0.91 CYP2A6 (0.56) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL23555855 0.89 CYP1A2 (0.72) CYP2A6CYP1A2ALDH1A1TDP1KDM4E
SCHEMBL19287326 0.86 CYP1A2 (0.68) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL9187014 0.86 CYP1A2 (0.68) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL13098708 0.86 ALDH1A1 (0.52) CYP2A6CYP1A2MAOBALDH1A1CYP11B1
SCHEMBL1247086 0.81 CYP2A6 (0.68) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL4659246 0.81 CYP11B1 (0.57) CYP2A6ALDH1A1CYP11B1CYP11B2KDM4E
SCHEMBL6313891 0.80 CYP2A6 (0.62) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL29827112 0.80 CYP2A6 (0.62) CYP2A6CYP1A2MAOBALDH1A1TDP1
SCHEMBL28941798 0.79 CYP2A6 (0.70) CYP2A6CYP1A2MAOBALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2311826-B1 NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME LG CHEMICAL LTD (KR) 2017-05-24 EP disclosed