Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18860557 | 0.85 | MAPK1 (0.50) | MAPK1METMEN1KMT2ANPC1 | |
| SCHEMBL18892042 | 0.83 | MAP4K1 (0.47) | MAPK1METMAP3K12 | |
| SCHEMBL18891653 | 0.81 | ROCK2 (0.43) | MAPK1METMAP3K12KDM4E | |
| SCHEMBL18891802 | 0.80 | ROCK2 (0.45) | MAPK1METMAP3K12KDM4EMAPT | |
| SCHEMBL21557641 | 0.79 | MAPK1 (0.48) | MAPK1METMAP3K12 | |
| SCHEMBL21557918 | 0.78 | MAPK1 (0.45) | MAPK1METMAP3K12 | |
| SCHEMBL18860564 | 0.74 | MET (0.44) | MAPK1METMEN1KMT2ANPC1 | |
| SCHEMBL21557872 | 0.74 | MAPK1 (0.47) | MAPK1METMAP3K12 | |
| SCHEMBL18892243 | 0.74 | MET (0.42) | MAPK1METMEN1KMT2ANPC1 | |
| SCHEMBL18891655 | 0.74 | LRRK2 (0.47) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |
| EP-3170822-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2017-05-24 | — | — | EP | disclosed |