Biphenyl

Biphenyl

SCHEMBL1889248

NC(=O)c1nccs1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.50
RBBP9 O75884 1/20 0.49
ALDH1A1 P00352 1/20 0.48
PDPK1 O15530 1/20 0.48
PLA2G4A P47712 1/20 0.48
CES1 P23141 1/20 0.47
CTSA P10619 1/20 0.43
SMO Q99835 1/20 0.43
SLC6A7 Q99884 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 2/20 0.42
SENP7 Q9BQF6 2/20 0.42
SENP6 Q9GZR1 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C19 P33261 1/20 0.42
AURKA O14965 1/20 0.41
PIM1 P11309 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27271103 0.91 ALDH1A1 (0.57) BCAT2RBBP9ALDH1A1PLA2G4ACES1
Naphthalene SCHEMBL10886899 0.87 ALDH1A1 (0.50) BCAT2RBBP9ALDH1A1PLA2G4ACES1
SCHEMBL158422 0.87
Biphenyl SCHEMBL18916766 0.85 ALDH1A1 (0.52) RBBP9ALDH1A1PDPK1PLA2G4ACES1
Potassium SCHEMBL31461086 0.85
Hydrochloric Acid SCHEMBL5013504 0.85 ALDH1A1 (0.59) RBBP9ALDH1A1PLA2G4ACES1CASP3
SCHEMBL31461084 0.85
SCHEMBL31461088 0.85
Hydrochloric Acid SCHEMBL27718659 0.85
Ammonia Solution, Strong SCHEMBL28224778 0.85

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103145640-A Biphenyl-thiazolo-carboxamides BAYER CROPSCIENCE AG 2013-06-12 CN claimed
CN-101044128-B Biphenylthiazolecarboxamides BAYER CROPSCIENCE AG 2012-04-18 CN claimed
US-20090105316-A1 Biphenyl Thiazole Carboxamides BAYER CROPSCIENCE AG (DE) 2009-04-23 US claimed
US-20080242708-A1 Biphenyl-Thiazolo-Carboxamides BAYER CROPSCIENCE AG (DE) 2008-10-02 US claimed
CN-101065369-A Biphenylthiazolecarboxamides BAYER CROPSCIENCE AG (DE) 2007-10-31 CN claimed
CN-101044128-A Biphenylthiazolecarboxamides BAYER CROPSCIENCE AG (DE) 2007-09-26 CN claimed
EP-1786794-A2 BIPHENYL-THIAZOLO-CARBOXAMIDES Bayer CropScience Aktiengesellschaft (DE) 2007-05-23 EP claimed
EP-1786795-A2 BIPHENYL THIAZOLE CARBOXAMIDES Bayer CropScience AG (DE) 2007-05-23 EP claimed
WO-2006024387-A2 BIPHENYL-THIAZOLO-CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO claimed
WO-2006024389-A2 BIPHENYL THIAZOLE CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO claimed
CN-103145640-A Biphenyl-thiazolo-carboxamides BAYER CROPSCIENCE AG 2013-06-12 CN disclosed
CN-103145640-A Biphenyl-thiazolo-carboxamides BAYER CROPSCIENCE AG 2013-06-12 CN disclosed
CN-103145640-A Biphenyl-thiazolo-carboxamides BAYER CROPSCIENCE AG 2013-06-12 CN disclosed
EP-1966147-B1 CARBOXAMIDES FOR CONTROLLING MICRO-ORGANISMS IN PLANT AND MATERIAL PROTECTION BAYER CROPSCIENCE AG (DE) 2012-08-08 EP disclosed
CN-101044128-B Biphenylthiazolecarboxamides BAYER CROPSCIENCE AG 2012-04-18 CN disclosed
WO-2006024387-A3 BIPHENYL-THIAZOLO-CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-05-11 WO disclosed
WO-2006024387-A2 BIPHENYL-THIAZOLO-CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO disclosed
WO-2006024387-A2 BIPHENYL-THIAZOLO-CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO disclosed
WO-2006024389-A2 BIPHENYL THIAZOLE CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO disclosed
WO-2006024389-A2 BIPHENYL THIAZOLE CARBOXAMIDES BAYER CROPSCIENCE AG (DE) 2006-03-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080242708-A1 Biphenyl-Thiazolo-Carboxamides MRPL21, CBR3, NAT1 BCAT2 404/4885RBBP9 910/4885ALDH1A1 123/4885
US-20090105316-A1 Biphenyl Thiazole Carboxamides MRPL21, CBR3, BRD4 BCAT2 221/4885RBBP9 689/4885ALDH1A1 151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.