Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15478402 | 0.93 | DRD2 (0.34) | — | |
| SCHEMBL15478335 | 0.90 | DRD2 (0.34) | — | |
| SCHEMBL15478334 | 0.86 | POLB (0.32) | POLBALDH1A1MAPTSMN1; SMN2KCNH2 | |
| SCHEMBL15478403 | 0.82 | DRD2 (0.36) | LMNAALDH1A1 | |
| SCHEMBL13824442 | 0.82 | CCR1 (0.49) | LMNATSHRHTTPOLBALDH1A1 | |
| SCHEMBL15478333 | 0.80 | DRD2 (0.40) | — | |
| SCHEMBL15478355 | 0.78 | CCR1 (0.38) | — | |
| SCHEMBL15478375 | 0.77 | CCR1 (0.50) | LMNATSHRHTTSMN1; SMN2USP2 | |
| SCHEMBL15478359 | 0.77 | CCR1 (0.38) | — | |
| SCHEMBL15478400 | 0.75 | CCR1 (0.37) | TSHRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |