SCHEMBL18896205

SCHEMBL18896205

CCCCCCNC(=O)c1cc(C)[nH]n1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.77
HDAC4 P56524 2/20 0.77
HDAC1 Q13547 2/20 0.77
HDAC7 Q8WUI4 2/20 0.77
HDAC2 Q92769 2/20 0.77
HDAC10 Q969S8 2/20 0.77
HDAC11 Q96DB2 2/20 0.77
HDAC8 Q9BY41 2/20 0.77
HDAC6 Q9UBN7 2/20 0.77
HDAC9 Q9UKV0 2/20 0.77
HDAC5 Q9UQL6 2/20 0.77
ALPL P05186 2/20 0.54
KDM4E B2RXH2 1/20 0.52
GPR84 Q9NQS5 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
CSNK2A2 P19784 1/20 0.49
KDR P35968 1/20 0.49
CSNK2B P67870 1/20 0.49
CSNK2A1 P68400 1/20 0.49
NAAA Q02083 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21467387 0.88 HDAC3 (0.67) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19607088 0.86 HDAC3 (0.74) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18896222 0.81 HDAC3 (0.61) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11349357 0.79 HCAR2 (0.66) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL162312 0.79 HDAC3 (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL23605697 0.79 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL19606807 0.78 HDAC3 (0.53) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL22984745 0.78 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL23605519 0.78 HDAC3 (0.62) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL21210723 0.75 NAAA (0.54) KDM4EGPR84L3MBTL1NAAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9663466-B2 Aryl dihydropyridinones and piperidinone MGAT2 inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-05-30 US disclosed