Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15861759 | 0.98 | NAAA (0.51) | NAAAKDM4EL3MBTL1GPR84HPGD | |
| SCHEMBL5767559 | 0.94 | HTT (0.51) | NAAAKDM4EL3MBTL1GPR84HPGD | |
| SCHEMBL3144624 | 0.80 | CNR1 (0.41) | KDM4EL3MBTL1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL22372130 | 0.80 | HPGD (0.52) | KDM4EL3MBTL1HPGDALDH1A1LMNA | |
| SCHEMBL24688731 | 0.78 | PLA2G2C (0.40) | — | |
| SCHEMBL25767541 | 0.77 | KMT2A (0.43) | NAAAKDM4EL3MBTL1TSHR | |
| SCHEMBL13299193 | 0.77 | POLB (0.56) | HPGDALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL30545065 | 0.76 | HPGD (0.64) | NAAAKDM4EL3MBTL1HPGDMLYCD | |
| SCHEMBL18896205 | 0.75 | HDAC3 (0.77) | NAAAKDM4EL3MBTL1GPR84ALDH1A1 | |
| SCHEMBL29126825 | 0.74 | ALDH1A1 (0.55) | KDM4EL3MBTL1GPR84ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10988477-B2 | GCN2 inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2021-04-27 | — | — | US | disclosed |
| US-20190233425-A1 | GCN2 INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10988477-B2 | GCN2 inhibitors and uses thereof | EIF2AK4, GCN1, EIF2AK1 | NAAA 3292/4885KDM4E 2118/4885L3MBTL1 902/4885 |
| US-20190233425-A1 | GCN2 INHIBITORS AND USES THEREOF | EIF2AK4, GCN1, GCGR | NAAA 2404/4885KDM4E 3944/4885L3MBTL1 2553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.