Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.58 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21467394 | 0.85 | MEN1 (0.71) | GAALMNAKDM4EPOLBHDAC3 | |
| SCHEMBL27744991 | 0.83 | GAA (0.54) | GAALMNAKDM4EPOLBHDAC3 | |
| SCHEMBL31444904 | 0.82 | POLB (0.56) | GAALMNAKDM4EPOLBHDAC3 | |
| SCHEMBL3377192 | 0.80 | GAA (0.63) | GAALMNAPOLBMEN1KMT2A | |
| SCHEMBL24433080 | 0.79 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2LMNAMEN1 | |
| SCHEMBL6366571 | 0.79 | ALDH1A1 (0.59) | TAS1R3TAS1R1TAS1R2LMNAKDM4E | |
| SCHEMBL9280891 | 0.79 | TAS1R3 (0.57) | TAS1R3TAS1R1TAS1R2LMNAKDM4E | |
| SCHEMBL3341029 | 0.78 | SMN1; SMN2 (0.50) | TAS1R3TAS1R1TAS1R2GAALMNA | |
| SCHEMBL29816280 | 0.77 | TAS1R3 (0.47) | TAS1R3TAS1R1TAS1R2TDP1SMN1; SMN2 | |
| SCHEMBL24567579 | 0.77 | GAA (0.59) | GAALMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663466-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-30 | — | — | US | disclosed |