Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27369921 | 0.83 | TLR8 (0.46) | CYP3A4CYP2C19CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL8093058 | 0.82 | TLR8 (0.51) | CLK4DYRK1ATLR8TP53MAPT | |
| SCHEMBL8653314 | 0.82 | TLR8 (0.48) | CYP3A4CYP2C19CLK4DYRK1ATLR8 | |
| SCHEMBL13540957 | 0.81 | DYRK1A (0.53) | CYP2C19CYP2E1CYP2A6CYP2C9CYP2B6 | |
| SCHEMBL12304948 | 0.79 | CYP17A1 (0.46) | CYP3A4CYP2C19CLK4DYRK1ATLR8 | |
| SCHEMBL2910946 | 0.78 | CYP2E1 (0.67) | CYP3A4CYP2C19CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL27690834 | 0.78 | CYP2E1 (0.58) | CYP3A4CYP2C19CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL22868032 | 0.77 | GPR55 (0.57) | CYP3A4TLR8TP53MAPTHSD17B10 | |
| SCHEMBL12250998 | 0.77 | DYRK1A (0.49) | CLK4DYRK1ATLR8TP53MAPT | |
| SCHEMBL1179688 | 0.76 | RAB9A (0.50) | CYP2C9CLK4DYRK1ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |