Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19592371 | 0.92 | CTSL (0.31) | CTSL | |
| SCHEMBL21316588 | 0.87 | MEN1 (0.33) | CTSLMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL9918194 | 0.84 | CTSL (0.32) | CTSLMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL18896345 | 0.82 | RAF1 (0.32) | CYP11B1CYP11B2 | |
| SCHEMBL19592391 | 0.78 | — | — | |
| SCHEMBL9921702 | 0.78 | MEN1 (0.34) | CTSLMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL19592265 | 0.74 | HDAC6 (0.33) | — | |
| SCHEMBL27875862 | 0.74 | POLB (0.38) | CTSLMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL24767572 | 0.73 | CTSB (0.31) | CYP11B1CYP11B2 | |
| SCHEMBL19592353 | 0.72 | PBRM1 (0.37) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9662335-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |