Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.37 |
| ▸ | IDH1 | O75874 | 5/20 | 0.36 |
| ▸ | IDH2 | P48735 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24650224 | 0.76 | SYK (0.47) | MAPK8HRH4IDH1IDH2ABL1 | |
| SCHEMBL12411108 | 0.73 | IDH1 (0.50) | MAPK8HRH4IDH1IDH2ABL1 | |
| SCHEMBL8000248 | 0.71 | IDH1 (0.53) | MAPK8HRH4IDH1IDH2SYK | |
| SCHEMBL19203477 | 0.70 | MAPK8 (0.39) | MAPK8HRH4IDH1ABL1LCK | |
| SCHEMBL5516162 | 0.64 | TDP1 (0.44) | KCNH3 | |
| SCHEMBL91488 | 0.64 | HRH4 (0.50) | MAPK8HRH4ABL1LCKCSF1R | |
| SCHEMBL2844731 | 0.64 | ABL1 (0.52) | MAPK8HRH4ABL1LCKCSF1R | |
| SCHEMBL10219318 | 0.63 | HTR7 (0.53) | IDH1LCKSYK | |
| SCHEMBL84413 | 0.62 | HRH4 (0.49) | MAPK8HRH4IDH1ABL1LCK | |
| SCHEMBL14999425 | 0.62 | HRH4 (0.49) | MAPK8HRH4ABL1LCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663520-B2 | Bicyclic bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-05-30 | — | — | US | disclosed |
| US-9662311-B2 | Substituted bicyclic compounds as bromodomain inhibitors | ZENITH EPIGENETICS LTD. (CA) | 2017-05-30 | — | — | US | disclosed |