Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15206544 | 0.99 | PIM1 (0.49) | PIM1PIM2HTR3EHTR3BHTR3A | |
| Chloromethane SCHEMBL15205595 | 0.96 | PIM1 (0.47) | PIM1PIM2HTR3EHTR3BHTR3A | |
| SCHEMBL29449945 | 0.89 | SLC6A2 (0.54) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL1322886 | 0.89 | SLC6A2 (0.54) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| Hydrochloric Acid SCHEMBL27696929 | 0.88 | SLC6A2 (0.53) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL13956071 | 0.88 | KDM4E (0.52) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| SCHEMBL28246553 | 0.86 | S1PR1 (0.53) | PIM1PIM2POLBLMNATP53 | |
| SCHEMBL15205714 | 0.84 | — | — | |
| SCHEMBL8805531 | 0.84 | NPC1 (0.46) | HTR3EHTR3BHTR3AHTR5AHTR3D | |
| Hydrochloric Acid SCHEMBL15205594 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016128987-A1 | A PROCESS FOR PREPARATION OF 2-BENZOFURANCARBOXAMIDE, 5-[4-[4-(5CYANO-1H-INDOL-3-YL)BUTYL]-1-PIPERAZINYL] FREE BASE AND ITS HYDROCHLORIDE SALT | HARMAN FINOCHEM LIMITED (IN) | 2016-08-18 | — | — | WO | claimed |
| CN-103467422-B | A kind of method preparing vilazodone intermediate 5-piperazinyl-2-acyl substituted cumarone | SHAANXI BUCHANG HIGH-TECH PHARMACEUTICAL CO., LTD. (CN) | 2016-02-24 | — | — | CN | claimed |
| EP-0738722-A1 | 5-Amino-benzofuran-2-carboxylic acid derivatives | MERCK PATENT GmbH (DE) | 1996-10-23 | — | — | EP | claimed |
| CN-108456198-B | Preparation method of vilazodone or hydrochloride thereof | 江苏豪森药业集团有限公司 | 2021-11-26 | — | — | CN | disclosed |
| CN-110092778-B | Method for preparing vilazodone intermediate and vilazodone medicine by using cheap metal copper | 浙江工业大学 | 2021-02-09 | — | — | CN | disclosed |
| CN-107501159-B | Synthesis method of vilazodone intermediate 3- (4-chlorobutyl) -5-cyanoindole | 连云港恒运药业有限公司 | 2020-11-24 | — | — | CN | disclosed |
| CN-109251200-A | A kind of preparation method of Vilazodone Hydrochloride | 江苏永安制药有限公司 | 2019-01-22 | — | — | CN | disclosed |
| CN-108003062-A | A kind of synthetic method of list BOC protections bisamination compound | 常州吉恩药业有限公司 | 2018-05-08 | — | — | CN | disclosed |
| WO-2016128987-A1 | A PROCESS FOR PREPARATION OF 2-BENZOFURANCARBOXAMIDE, 5-[4-[4-(5CYANO-1H-INDOL-3-YL)BUTYL]-1-PIPERAZINYL] FREE BASE AND ITS HYDROCHLORIDE SALT | HARMAN FINOCHEM LIMITED (IN) | 2016-08-18 | — | — | WO | disclosed |
| EP-2647625-B1 | Process for preparing vilazodone hydrochloride | ERREGIERRE SPA (IT) | 2015-10-21 | — | — | EP | disclosed |
| CN-103910717-A | Novel 5-(4-(4-(5-cyan-1H-indole-3-group)butyl)piperazine-1-group)coumarone-2-formic acid preparation method | WUXI WANQUAN MEDICAL TECHNOLOGY CO LTD | 2014-07-09 | — | — | CN | disclosed |
| WO-2014012505-A1 | METHOD FOR PREPARING VILAZODONE AND INTERMEDIATE THEREOF | 江苏先声药物研究有限公司 (CN) | 2014-01-23 | — | — | WO | disclosed |
| US-8575161-B2 | Benzofurane, benzothiophene, benzothiazol derivatives as FXR modulators | MERCK PATENT GMBH (DE) | 2013-11-05 | — | — | US | disclosed |
| EP-2647625-A1 | Process for preparing vilazodone hydrochloride | ERREGIERRE S.p.A. (IT) | 2013-10-09 | — | — | EP | disclosed |
| CN-103304526-A | Novel preparation method of 5-(piperazin-yl)benzofuran-2-formic acid | WUXI WANQUAN MEDICAL TECHNOLOGY CO LTD | 2013-09-18 | — | — | CN | disclosed |
| CN-103304526-A | Novel preparation method of 5-(piperazin-yl)benzofuran-2-formic acid | WUXI WANQUAN MEDICAL TECHNOLOGY CO LTD | 2013-09-18 | — | — | CN | disclosed |
| US-20110105475-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | MERXCK PATENT GESELLSCHAFT (DE) | 2011-05-05 | — | — | US | disclosed |
| EP-0648767-B1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GMBH (DE) | 1997-05-28 | — | — | EP | disclosed |
| US-5532241-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0648767-A1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GmbH (DE) | 1995-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105475-A1 | BENZOFURANE, BENZOTHIOPHENE, BENZOTHIAZOL DERIVATIVES AS FXR MODULATORS | FXR1, FXR2, NR1H4 | PIM1 4649/4885PIM2 4563/4885HTR3E 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.