SCHEMBL18901016

SCHEMBL18901016

COc1cccc(CNI)c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
MAPT P10636 2/20 0.43
GAA P10253 1/20 0.43
CHRM2 P08172 12/20 0.40
GRIN1 Q05586 4/20 0.40
GRIN2A Q12879 4/20 0.40
BCHE P06276 4/20 0.40
ACHE P22303 4/20 0.40
CHRM4 P08173 4/20 0.40
CHRM5 P08912 4/20 0.40
CHRM1 P11229 4/20 0.40
CHRM3 P20309 4/20 0.40
KDM4E B2RXH2 1/20 0.40
SLC6A2 P23975 1/20 0.40
SLC6A4 P31645 1/20 0.40
SLC6A3 Q01959 1/20 0.40
KCNH2 Q12809 1/20 0.40
TP53 P04637 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17790193 0.84 SLC6A4 (0.55) ALDH1A1MAPTGAAGRIN1GRIN2A
SCHEMBL19091168 0.81 ALDH1A1 (0.63) ALDH1A1MAPTGAACHRM2GRIN1
SCHEMBL18901363 0.80 ALDH1A1 (0.56) ALDH1A1MAPTGAABCHEKDM4E
SCHEMBL17266361 0.79 IDO1 (0.41) ALDH1A1MAPTGAACHRM2CHRM1
SCHEMBL7672632 0.79 IDO1 (0.41) ALDH1A1MAPTGAACHRM2CHRM1
SCHEMBL17788600 0.79 PDCD1LG2 (0.50) ALDH1A1MAPTGAACHRM2GRIN1
SCHEMBL18901017 0.77 PNMT (0.54) ALDH1A1MAPTGAACHRM2CHRM1
SCHEMBL8340504 0.77 KDM4E (0.45) MAPTCHRM2CHRM1KDM4E
SCHEMBL1415272 0.77 IDO1 (0.42) ALDH1A1MAPTGAACHRM2CHRM1
SCHEMBL736332 0.77 MEN1 (0.54) ALDH1A1GAABCHEACHEKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3016951-B1 TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-05-31 EP disclosed