SCHEMBL1890103

SCHEMBL1890103

CCCCCCCCC=CCCCCCCCC(=O)C(C)(C)C(C)(CN)C(=O)CCCCCCCC=CCCCCCCCC

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 7/20 0.58
CES1 P23141 2/20 0.58
CYP1A2 P05177 2/20 0.56
CYP2C19 P33261 2/20 0.56
KMT2A Q03164 2/20 0.56
SOAT1 P35610 2/20 0.56
MEN1 O00255 1/20 0.56
TP53 P04637 1/20 0.56
CYP3A4 P08684 1/20 0.56
TERT O14746 3/20 0.51
PTPN1 P18031 3/20 0.51
PPARG P37231 3/20 0.51
PPARD Q03181 3/20 0.51
PPARA Q07869 3/20 0.51
MAPT P10636 2/20 0.51
BLM P54132 2/20 0.51
HSD17B10 Q99714 2/20 0.51
FABP4 P15090 2/20 0.51
GMNN O75496 1/20 0.51
USP2 O75604 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29110836 0.91 FAAH (0.50) FAAHCES1CYP1A2KMT2AMEN1
SCHEMBL28044207 0.85 FAAH (0.71) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL28818411 0.83 FAAH (0.52) FAAHCES1CYP1A2CYP2C19KMT2A
Hydrochloric Acid SCHEMBL29006654 0.82 FAAH (0.67) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL9354962 0.81 FAAH (0.65) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL8935063 0.81 FAAH (0.65) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL29072795 0.80 FAAH (0.63) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL723655 0.80 FAAH (0.63) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL9330785 0.79 FAAH (0.67) FAAHCES1CYP1A2CYP2C19KMT2A
SCHEMBL31280143 0.79 FAAH (0.67) FAAHCES1CYP1A2CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2507374-B1 NOVEL THERAPEUTIC RNA INTERFERENCE TECHNOLOGY TARGETED TO THE PDX-1 ONCOGENE IN PDX-1 EXPRESSING NEUROENDOCRINE TUMORS STRIKE BIO INC (US) 2016-12-07 EP disclosed
US-9133459-B2 Therapeutic RNA interference technology targeted to the PDX-1 oncogene in PDX-1 expressing neuroendocrine tumors STRIKE BIO, INC. (US) 2015-09-15 US disclosed
US-8906874-B2 Bi-functional shRNA targeting Stathmin 1 and uses thereof GRADALIS, INC. (US) 2014-12-09 US disclosed
US-20130295160-A1 ANTAGONISTS OF MIR-196A STRIKE BIO, INC. 2013-11-07 US disclosed
WO-2013151981-A1 EWING'S SARCOMA BIFUNCTIONAL SHRNA DESIGN GRADALIS, INC. (US) 2013-10-10 WO disclosed
US-20130266639-A1 METHODS FOR TREATING TRIPLE NEGATIVE BREAST CANCER USING BIFUNCTIONAL SRC 3 shRNA STRIKE BIO, INC. 2013-10-10 US disclosed
US-20130259925-A1 METHODS AND COMPOSITIONS TO TREAT CANCER USING BIFUNCTIONAL SRC 3 shRNA BAYLOR COLLEGE OF MEDICINE (US) 2013-10-03 US disclosed
US-20130259927-A1 Ewing's Sarcoma Bifunctional shRNA Design GRADALIS, INC. (US) 2013-10-03 US disclosed
WO-2013148824-A1 METHODS AND COMPOSITIONS TO TREAT CANCER USING BIFUNCTIONAL SRC-3 shRNA GRADALIS, INC. (US) 2013-10-03 WO disclosed
US-20130084331-A1 Novel Therapeutic RNA Interference Technology Targeted to the PDX-1 Oncogene in PDX-1 Expressing Neuroendocrine Tumors BAYLOR COLLEGE OF MEDICINE (US) 2013-04-04 US disclosed
US-20130064881-A1 COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER GRADALIS, INC. (US) 2013-03-14 US disclosed
US-8361983-B2 Therapeutic RNA interference technology targeted to the PDX-1 oncogene in PDX-1 expressing neuroendocrine tumors GRADALIS, INC. (US) 2013-01-29 US disclosed
EP-2507374-A2 NOVEL THERAPEUTIC RNA INTERFERENCE TECHNOLOGY TARGETED TO THE PDX-1 ONCOGENE IN PDX-1 EXPRESSING NEUROENDOCRINE TUMORS Gradalis, Inc. (US) 2012-10-10 EP disclosed
US-20120251617-A1 BI-FUNCTIONAL SHRNA TARGETING STATHMIN 1 AND USES THEREOF GRADALIS, INC. (US) 2012-10-04 US disclosed
US-20110117183-A1 Novel Therapeutic RNA Interference Technology Targeted to the PDX-1 Oncogene in PDX-1 Expressing Neuroendocrine Tumors GRADALIS, INC. (US) 2011-05-19 US disclosed
WO-2011053660-A2 NOVEL THERAPEUTIC RNA INTERFERENCE TECHNOLOGY TARGETED TO THE PDX-1 ONCOGENE IN PDX-1 EXPRESSING NEUROENDOCRINE TUMORS GRADALIS, INC. (US) 2011-05-05 WO disclosed
WO-2009062104-A2 ABERRANT EXPRESSION OF ZINC TRANSPORTER ZIP4 (SLC39A4) SIGNIFICANTLY CONTRIBUTES TO HUMAN PANCREATIC CANCER PATHOGENESIS AND PROGRESSION BAYLOR COLLEGE OF MEDICINE (US) 2009-05-14 WO disclosed