Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16345008 | 0.82 | ROCK2 (0.62) | ROCK2PARP1CSNK2A1PTGER4 | |
| SCHEMBL16344952 | 0.82 | ROCK2 (0.48) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL16345009 | 0.80 | ROCK2 (0.47) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL18901407 | 0.80 | ROCK2 (0.47) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL16345052 | 0.79 | ROCK2 (0.66) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL16345968 | 0.78 | ROCK2 (0.62) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL16345042 | 0.77 | ROCK2 (0.62) | ROCK2PARP1CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL17788677 | 0.77 | ROCK2 (0.44) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL17788678 | 0.77 | ROCK2 (0.47) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 | |
| SCHEMBL26966715 | 0.71 | CYP2D6 (0.65) | ROCK2PARP1CSNK2A1PTGER4CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |
| EP-3016951-B1 | TRICYCLIC PYRIDO-CARBOXAMIDE DERIVATIVES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-05-31 | — | — | EP | disclosed |