Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.65 |
| ▸ | NAMPT | P43490 | 8/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901516 | 0.88 | CCR2 (0.54) | CCR2NAMPTKDM1AMAOAMAOB | |
| SCHEMBL18901509 | 0.87 | NAMPT (0.55) | CCR2NAMPTKDM4EUSP2ALDH1A1 | |
| SCHEMBL18901621 | 0.85 | CCR2 (0.52) | CCR2NAMPTCCR5 | |
| SCHEMBL10738116 | 0.84 | CCR2 (0.52) | CCR2NAMPTKDM4EUSP2ALDH1A1 | |
| SCHEMBL18901434 | 0.82 | NAMPT (0.44) | CCR2NAMPTKDM4EUSP2ALDH1A1 | |
| SCHEMBL10743874 | 0.80 | CNR1 (0.53) | CCR2NAMPTKDM4EUSP2ALDH1A1 | |
| SCHEMBL3322634 | 0.79 | CCR2 (1.00) | CCR2CCR5 | |
| SCHEMBL14011045 | 0.79 | CCR2 (1.00) | CCR2CCR5 | |
| SCHEMBL18901610 | 0.79 | POLB (0.64) | CCR2CCR5USP2ALDH1A1TSHR | |
| SCHEMBL18901526 | 0.79 | CCR2 (0.64) | CCR2NAMPTKDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |