Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 13/20 | 0.54 |
| ▸ | CCR5 | P51681 | 11/20 | 0.48 |
| ▸ | NAMPT | P43490 | 5/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901621 | 0.90 | CCR2 (0.52) | CCR2CCR5NAMPT | |
| SCHEMBL18901544 | 0.88 | NAMPT (0.50) | NAMPT | |
| SCHEMBL18901437 | 0.88 | CCR2 (0.65) | CCR2CCR5NAMPTKDM1AMAOA | |
| SCHEMBL3325857 | 0.82 | CCR2 (0.81) | CCR2CCR5 | |
| SCHEMBL14011048 | 0.82 | CCR2 (0.81) | CCR2CCR5 | |
| SCHEMBL18901618 | 0.81 | CCR2 (0.67) | CCR2CCR5 | |
| SCHEMBL18901830 | 0.81 | CCR2 (0.53) | CCR2CCR5 | |
| SCHEMBL18901614 | 0.81 | CCR2 (0.67) | CCR2CCR5 | |
| SCHEMBL10738116 | 0.80 | CCR2 (0.52) | CCR2NAMPT | |
| SCHEMBL18901558 | 0.79 | CCR2 (0.42) | CCR2CCR5NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |