Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CCR5 | P51681 | 5/20 | 0.44 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901621 | 0.87 | CCR2 (0.52) | CCR2KCNH2CCR5NAMPT | |
| SCHEMBL18901558 | 0.85 | CCR2 (0.42) | CCR2KCNH2CCR5NAMPT | |
| SCHEMBL3326416 | 0.83 | CCR2 (0.72) | CCR2KCNH2CCR5 | |
| SCHEMBL14011057 | 0.83 | CCR2 (0.72) | CCR2KCNH2CCR5 | |
| SCHEMBL18901675 | 0.82 | CCR2 (0.69) | CCR2KCNH2CCR5 | |
| SCHEMBL18901551 | 0.80 | SYK (0.46) | MAP3K12 | |
| SCHEMBL18901821 | 0.76 | TRPV1 (0.39) | MAP3K12NAMPT | |
| SCHEMBL18901516 | 0.76 | CCR2 (0.54) | CCR2CCR5NAMPT | |
| SCHEMBL18901425 | 0.76 | CCR2 (0.68) | CCR2KCNH2CCR5 | |
| SCHEMBL18901697 | 0.75 | CCR2 (0.54) | CCR2KCNH2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |