Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | CCR2 | P41597 | 9/20 | 0.63 |
| ▸ | CCR5 | P51681 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901610 | 1.00 | POLB (0.64) | POLBCCR2CCR5LMNATSHR | |
| SCHEMBL18901424 | 0.90 | CCR2 (0.60) | POLBCCR2CCR5 | |
| SCHEMBL18901807 | 0.89 | CCR2 (0.61) | POLBCCR2CCR5SMN1; SMN2MAPT | |
| SCHEMBL18901614 | 0.86 | CCR2 (0.67) | POLBCCR2CCR5 | |
| SCHEMBL18901618 | 0.86 | CCR2 (0.67) | POLBCCR2CCR5 | |
| SCHEMBL18901526 | 0.84 | CCR2 (0.64) | POLBCCR2CCR5 | |
| SCHEMBL18901425 | 0.84 | CCR2 (0.68) | POLBCCR2CCR5 | |
| SCHEMBL4161857 | 0.84 | POLB (0.69) | POLBLMNATSHRSMN1; SMN2USP2 | |
| SCHEMBL10993938 | 0.83 | POLB (0.90) | POLBLMNATSHRSMN1; SMN2USP2 | |
| SCHEMBL18901537 | 0.82 | CCR2 (0.70) | POLBCCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |