Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18901424 | 0.90 | CCR2 (0.60) | CCR2AKR1C3EPHX2CCR5TDP1 | |
| SCHEMBL18901610 | 0.89 | POLB (0.64) | CCR2CCR5POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL18901533 | 0.89 | POLB (0.64) | CCR2CCR5POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL18901612 | 0.82 | AKR1C3 (0.57) | CCR2AKR1C3EPHX2CCR5SMN1; SMN2 | |
| SCHEMBL18901526 | 0.79 | CCR2 (0.64) | CCR2EPHX2CCR5POLBNAMPT | |
| SCHEMBL14100727 | 0.79 | CCR2 (0.63) | CCR2EPHX2 | |
| SCHEMBL19337949 | 0.79 | CCR2 (0.63) | CCR2EPHX2 | |
| SCHEMBL18901614 | 0.76 | CCR2 (0.67) | CCR2CCR5POLB | |
| SCHEMBL18901618 | 0.76 | CCR2 (0.67) | CCR2CCR5POLB | |
| SCHEMBL13361937 | 0.75 | CCR2 (0.84) | CCR2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763351-B9 | 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS | INCYTE HOLDINGS CORP (US) | 2017-05-31 | — | — | EP | disclosed |