Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.52 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | IL1B | P01584 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328540 | 0.88 | DDB1 (0.56) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18900389 | 0.74 | DDB1 (0.43) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL18900533 | 0.73 | CRBN (0.43) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19526076 | 0.72 | CRBN (0.42) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24250716 | 0.71 | CRBN (0.52) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL21426444 | 0.70 | DDB1 (0.69) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL19953931 | 0.68 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29922428 | 0.68 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL16209843 | 0.68 | DDB1 (1.00) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL20128674 | 0.68 | CRBN (0.56) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420498-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |