Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19526076 | 0.81 | CRBN (0.42) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL24113869 | 0.76 | CRBN (0.58) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL283824 | 0.76 | CRBN (0.58) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL328540 | 0.73 | DDB1 (0.56) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL18904211 | 0.73 | CRBN (0.52) | CRBNDDB1TNFIL1BIKZF3 | |
| SCHEMBL282617 | 0.68 | CRBN (0.56) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL12638455 | 0.68 | CRBN (0.47) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL283159 | 0.68 | CRBN (0.60) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL282665 | 0.67 | CRBN (0.59) | CRBNCSNK1A1DDB1TNFIL1B | |
| SCHEMBL287793 | 0.67 | CRBN (0.54) | CRBNCSNK1A1DDB1TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-B1 | 5-substituted quinazolinone derivatives as anti-cancer agents | CELGENE CORP (US) | 2017-05-31 | — | — | EP | disclosed |