Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 20/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 20/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL1B | P01584 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904211 | 0.88 | CRBN (0.52) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL18900389 | 0.86 | DDB1 (0.43) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL18900533 | 0.73 | CRBN (0.43) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL21426444 | 0.73 | DDB1 (0.69) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL19526076 | 0.73 | CRBN (0.42) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL24250716 | 0.72 | CRBN (0.52) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL16209843 | 0.71 | DDB1 (1.00) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL19953931 | 0.71 | DDB1 (1.00) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL29922428 | 0.71 | DDB1 (1.00) | DDB1CRBNTNFIL1BIKZF3 | |
| SCHEMBL3653177 | 0.70 | CRBN (0.71) | DDB1CRBNTNFIL1BIKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428513-A1 | 5-substituted quinazolinone derivatives as anti-cancer agents | Celgene Corporation (US) | 2012-03-14 | — | — | EP | disclosed |