Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.71 |
| ▸ | MPL | P40238 | 4/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | WRN | Q14191 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 3/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 5/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13159796 | 0.87 | CHRNA7 (0.55) | CHRNA7MPLTDO2APEX1CYP1A2 | |
| Methane SCHEMBL27887103 | 0.85 | CHRNA7 (0.73) | CHRNA7MPLBLMWRNTDO2 | |
| SCHEMBL12158255 | 0.83 | CHRNA7 (1.00) | CHRNA7MPLBLMWRNTDO2 | |
| SCHEMBL1884904 | 0.75 | MAPT (0.64) | APEX1CYP1A1CYP1A2CYP1B1MAOA | |
| SCHEMBL12158245 | 0.75 | CHRNA7 (0.57) | CHRNA7MPLBLMWRNTDO2 | |
| SCHEMBL12639832 | 0.74 | ALDH1A1 (0.59) | APEX1CYP1A1CYP1A2CYP1B1DHODH | |
| SCHEMBL1885335 | 0.74 | DHODH (0.53) | CHRNA7APEX1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL12158251 | 0.73 | CHRNA7 (0.55) | CHRNA7MPLBLMWRNTDO2 | |
| SCHEMBL18904288 | 0.73 | CHRNA7 (0.63) | CHRNA7MPLBLMWRNTDO2 | |
| SCHEMBL18904197 | 0.73 | MAPT (0.52) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926719-B1 | 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-31 | — | — | EP | disclosed |