Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.42 |
| ▸ | TACR1 | P25103 | 5/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | ACACA | Q13085 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18964397 | 0.91 | ACACB (0.43) | ACACBTACR1PDE4APDE4BPDE4C | |
| SCHEMBL18820768 | 0.87 | ACACB (0.46) | ACACBTACR1PDE4APDE4BPDE4C | |
| SCHEMBL18820315 | 0.87 | ACACB (0.46) | ACACBTACR1PDE4APDE4BPDE4C | |
| SCHEMBL18908180 | 0.86 | ACACB (0.42) | ACACBTACR1PDE4APDE4BPDE4C | |
| SCHEMBL18909754 | 0.85 | ACACB (0.41) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18909759 | 0.85 | PDE4D (0.51) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18821278 | 0.83 | ACACB (0.43) | ACACBTACR1PDE4APDE4BPDE4C | |
| SCHEMBL18820854 | 0.78 | ACACA (0.37) | ACACBACACA | |
| SCHEMBL19361570 | 0.76 | CACNB4 (0.36) | ACACBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18883455 | 0.76 | ACACB (0.34) | ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017091602-A1 | ESTER ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |
| WO-2017091600-A1 | PYRAZOLE ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |