Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.51 |
| ▸ | ACACB | O00763 | 4/20 | 0.48 |
| ▸ | ACACA | Q13085 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18908167 | 0.90 | ACACB (0.49) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18907641 | 0.87 | ACACB (0.53) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL16245922 | 0.87 | ACACB (0.53) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18909758 | 0.86 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18909754 | 0.86 | ACACB (0.41) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18908179 | 0.86 | ACACB (0.48) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18909752 | 0.85 | ACACB (0.42) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL18907643 | 0.82 | ACACB (0.50) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL22000680 | 0.79 | ACACA (0.49) | PDE4DPDE4APDE4BPDE4CACACB | |
| SCHEMBL21816530 | 0.79 | ACACA (0.49) | PDE4DPDE4APDE4BPDE4CACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380478-B1 | ESTER ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO LLC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2017091602-A1 | ESTER ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |
| WO-2017091600-A1 | PYRAZOLE ACC INHIBITORS AND USES THEREOF | GILEAD APOLLO, LLC (US) | 2017-06-01 | — | — | WO | disclosed |