Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 8/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891199 | 0.92 | ANO1 (0.51) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1952255 | 0.88 | GRIN2C (0.61) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1954104 | 0.86 | ANO1 (0.74) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1954521 | 0.81 | ANO1 (0.64) | ANO1 | |
| SCHEMBL1907496 | 0.81 | ANO1 (0.83) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1953707 | 0.79 | GRIN2C (0.59) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1953247 | 0.78 | ANO1 (1.00) | ANO1 | |
| SCHEMBL7950809 | 0.74 | ANO1 (0.70) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1907632 | 0.74 | ANO1 (0.79) | ANO1GRIN2CMEN1KMT2ANPC1 | |
| SCHEMBL1897480 | 0.73 | ANO1 (0.61) | ANO1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321303-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | Calcimedica, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010027875-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2010-03-11 | — | — | WO | disclosed |