Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18912409 | 1.00 | LMNA (0.46) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL18906100 | 0.80 | ALDH1A1 (0.43) | LMNASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL18906101 | 0.80 | ALDH1A1 (0.43) | LMNASMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL18912408 | 0.75 | LMNA (0.47) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL13296438 | 0.73 | TSHR (0.63) | LMNAHTTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL10908184 | 0.73 | LMNA (0.59) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL187922 | 0.71 | ALDH1A1 (0.72) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL17795416 | 0.71 | LMNA (0.60) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL4085333 | 0.70 | CA12 (0.80) | LMNAHTTSMN1; SMN2MAPTGAA | |
| SCHEMBL3277847 | 0.70 | ALDH1A1 (0.77) | LMNAHTTSMN1; SMN2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994518-B2 | Alpha-7 nicotinic acetylcholine receptor modulators and uses thereof | MERCK SHARP & DOHME CORP. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170152221-A1 | ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152221-A1 | ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | CHRNA7, CHRNA10, CHRNA5 | LMNA 4029/4885HTT 1117/4885SMN1; SMN2 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.