SCHEMBL18912552

SCHEMBL18912552

NCCNC(=O)c1ccoc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.54
CYP1A2 P05177 1/20 0.54
TSHR P16473 1/20 0.54
NFKB1 P19838 1/20 0.54
HDAC3 O15379 1/20 0.53
HDAC1 Q13547 1/20 0.53
MEN1 O00255 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
KMT2A Q03164 1/20 0.53
TERT O14746 2/20 0.49
NOS3 P29474 1/20 0.48
NOS1 P29475 1/20 0.48
NOS2 P35228 1/20 0.48
KDM4E B2RXH2 1/20 0.48
KCNK3 O14649 1/20 0.43
KCNK9 Q9NPC2 1/20 0.43
PTK2 Q05397 1/20 0.41
RAB9A P51151 1/20 0.40
TRPA1 O75762 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16357638 0.90 HDAC3 (0.57) MAOBCYP1A2TSHRNFKB1HDAC3
SCHEMBL6360179 0.82 L3MBTL1 (0.50) MAOBHDAC3HDAC1KMT2ANOS3
SCHEMBL23844443 0.81 CA1 (0.50) CYP1A2HDAC3HDAC1NOS3NOS1
SCHEMBL10244781 0.79 SMN1; SMN2 (0.58) TSHRHDAC3HDAC1MEN1BLM
SCHEMBL3705840 0.79
SCHEMBL3861146 0.78 MAOB (0.81) MAOBCYP1A2TSHRNFKB1MEN1
SCHEMBL7365951 0.78 TRPA1 (0.59) HDAC3HDAC1MEN1KMT2ARAB9A
SCHEMBL3273821 0.78 PTK2 (0.50) HDAC3HDAC1KCNK3KCNK9PTK2
SCHEMBL31530559 0.77 HSD17B10 (0.65) HDAC3HDAC1MEN1KMT2AKDM4E
SCHEMBL18912249 0.76 KDM4E (0.53) TSHRHDAC3HDAC1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170152443-A1 LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT CHI MEI CORPORATION (TW) 2017-06-01 US disclosed