Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | FURIN | P09958 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18913047 | 1.00 | CTSS (0.43) | CTSSCTSKL3MBTL1BIRC2RECQL | |
| SCHEMBL22892480 | 0.85 | MME (0.53) | CTSSCTSKL3MBTL1HTTMME | |
| SCHEMBL22892432 | 0.85 | MME (0.53) | CTSSCTSKL3MBTL1HTTMME | |
| SCHEMBL28706003 | 0.85 | MME (0.53) | CTSSCTSKL3MBTL1HTTMME | |
| SCHEMBL22860838 | 0.81 | CTSS (0.42) | CTSSCTSKL3MBTL1BIRC2RECQL | |
| SCHEMBL28051158 | 0.81 | CTSS (0.42) | CTSSCTSKL3MBTL1BIRC2HTT | |
| SCHEMBL28051156 | 0.81 | CTSS (0.42) | CTSSCTSKL3MBTL1BIRC2HTT | |
| SCHEMBL16550867 | 0.78 | CTSS (0.69) | CTSSCTSKHTTCA2ALDH1A1 | |
| SCHEMBL22636434 | 0.78 | POLB (0.46) | HTTALDH1A1KDM4E | |
| SCHEMBL22648533 | 0.78 | POLB (0.46) | HTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723766-B2 | Derivatives of gamma-amanitin | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-07-28 | — | — | US | disclosed |
| WO-2017089607-A1 | DERIVATIVES OF GAMMA-AMANITIN | HEIDELBERG PHARMA GMBH (DE) | 2017-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723766-B2 | Derivatives of gamma-amanitin | MGAT2, MGAT3, MGAT1 | CTSS 3623/4885CTSK 2756/4885L3MBTL1 2309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.