SCHEMBL18913307

SCHEMBL18913307

CC1(C)CC(=O)N(c2cccc(N3C(=O)CC(C)(C)CC3=O)c2)C(=O)C1

nearest known ligand 0.80

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.80
MEN1 O00255 4/20 0.80
PKM P14618 1/20 0.60
POLB P06746 1/20 0.54
L3MBTL1 Q9Y468 3/20 0.52
MAPT P10636 4/20 0.48
HSD17B10 Q99714 2/20 0.48
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
HPGD P15428 1/20 0.48
CASP1 P29466 1/20 0.48
CASP7 P55210 1/20 0.48
MGLL Q99685 3/20 0.47
FAAH O00519 2/20 0.47
HSP90AA1 P07900 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10855744 0.89 MEN1 (0.71) KMT2AMEN1PKMPOLBL3MBTL1
SCHEMBL16395879 0.86 MEN1 (0.66) KMT2AMEN1PKMPOLBALDH1A1
SCHEMBL18893649 0.83 POLB (0.72) KMT2AMEN1PKMPOLBMAPT
SCHEMBL10853175 0.77 KMT2A (0.55) KMT2AMEN1PKMPOLBL3MBTL1
SCHEMBL29749910 0.76 L3MBTL1 (0.73) KMT2AMEN1PKMPOLBL3MBTL1
SCHEMBL16395894 0.76 POLB (0.64) KMT2AMEN1PKMPOLBMAPT
SCHEMBL6140676 0.76 POLB (0.64) KMT2AMEN1PKMPOLBMAPT
SCHEMBL5649903 0.74 POLB (0.62) KMT2AMEN1PKMPOLBMAPT
SCHEMBL11480980 0.74 POLB (0.57) KMT2AMEN1PKMPOLBMAPT
SCHEMBL2510494 0.72 AR (0.52) KMT2AMEN1PKML3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3204355-B1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF COMMW SCIENT IND RES ORG (AU) 2022-06-22 EP disclosed
US-10315994-B2 Photostable compounds, absorbing compounds and uses thereof COMMOMWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION (AU) 2019-06-11 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-20180016233-A1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR GANISATION (AU) 2018-01-18 US disclosed
US-20180016233-A1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR GANISATION (AU) 2018-01-18 US disclosed
WO-2017088031-A1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2017-06-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180016233-A1 PHOTOSTABLE COMPOUNDS, ABSORBING COMPOUNDS AND USES THEREOF PCNA, SLC19A1, ERCC4 KMT2A 1407/4885MEN1 123/4885PKM 1727/4885
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof ERCC1, ERCC4, ERCC5 KMT2A 1668/4885MEN1 395/4885PKM 2543/4885
US-10315994-B2 Photostable compounds, absorbing compounds and uses thereof PCNA, SLC19A1, ERCC4 KMT2A 1407/4885MEN1 123/4885PKM 1727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.