Sugi Predict

Sugi Predict / Compounds / SCHEMBL18918286

SCHEMBL18918286

SCHEMBL18918286

CC(CC(Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.42
▸ PPARG P37231 1/20 0.41
▸ PPARA Q07869 1/20 0.41
▸ MME P08473 5/20 0.41
▸ MMEL1 Q495T6 3/20 0.41
▸ GRM4 Q14833 1/20 0.41
▸ ACE P12821 2/20 0.40
▸ ALB P02768 1/20 0.40
▸ IL2 P60568 1/20 0.40
▸ ITGA4 P13612 1/20 0.39
▸ ITGB7 P26010 1/20 0.39
▸ APP P05067 3/20 0.39
▸ BCL2 P10415 1/20 0.38
▸ MCL1 Q07820 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18918287 1.00 ATM (0.42) ATMPPARGPPARAMMEMMEL1
SCHEMBL29390410 1.00 ATM (0.42) ATMPPARGPPARAMMEMMEL1
SCHEMBL28337627 1.00 ATM (0.42) ATMPPARGPPARAMMEMMEL1
SCHEMBL20529431 0.92 ITGA4 (0.41) ATMPPARGPPARAGRM4ALB
SCHEMBL20529435 0.92 ITGA4 (0.41) ATMPPARGPPARAGRM4ALB
SCHEMBL20529432 0.92 ITGA4 (0.41) ATMPPARGPPARAGRM4ALB
SCHEMBL31235844 0.92 ITGA4 (0.41) ATMPPARGPPARAGRM4ALB
SCHEMBL15433020 0.89 ALDH1A1 (0.39) ATMPPARGPPARAGRM4ALB
SCHEMBL30134429 0.89 ALDH1A1 (0.39) ATMPPARGPPARAGRM4ALB
SCHEMBL28509153 0.87 ALDH1A1 (0.42) ATMPPARGPPARAMMEMMEL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-12-05 — — US disclosed
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2023-09-26 — — US disclosed
CN-110099682-B Coupled connector, cell binding molecule-drug conjugate containing same, and preparation and application thereof 杭州多禧生物科技有限公司 2023-03-31 — — CN disclosed
CN-109912683-B Cytotoxin molecule, conjugate, preparation method and application thereof 杭州多禧生物科技有限公司 2023-01-06 — — CN disclosed
CN-115505029-A Cytotoxin molecule, conjugate, preparation method and application thereof 杭州多禧生物科技有限公司 2022-12-23 — — CN disclosed
EP-3210627-B1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO LTD (CN) 2022-12-21 — — EP disclosed
CN-113195487-A 2, 3-diaminosuccinyl conjugate linkers 杭州多禧生物科技有限公司 2021-07-30 — — CN disclosed
CN-112826940-A Conjugates of cytotoxic molecules and cell-binding receptor molecules 杭州多禧生物科技有限公司 2021-05-25 — — CN disclosed
CN-105641707-B Conjugates of cytotoxic molecules and cell-binding receptor molecules 杭州多禧生物科技有限公司 2020-11-24 — — CN disclosed
EP-2872157-B1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO LTD (CN) 2020-01-22 — — EP disclosed
CN-110621673-A Double-stranded linked cytotoxic drug conjugates 杭州多禧生物科技有限公司 2019-12-27 — — CN disclosed
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-10-31 — — US disclosed
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2019-09-03 — — US disclosed
EP-3348280-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2018-07-18 — — EP disclosed
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2018-01-25 — — US disclosed
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents HANGZHOU DAC BIOTECH CO., LTD. (CN) 2017-10-19 — — US disclosed
EP-3210627-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS Hangzhou Dac Biotech Co., Ltd (CN) 2017-08-30 — — EP disclosed
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS HANGZHOU DAC BIOTECH CO., LTD (CN) 2017-06-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190330149-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 ATM 3020/4885PPARG 4835/4885PPARA 4715/4885
US-10399941-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3020/4885PPARG 4835/4885PPARA 4715/4885
US-20170157262-A1 CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS CD4, CD2, CD47 ATM 2988/4885PPARG 4833/4885PPARA 4754/4885
US-11767294-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3020/4885PPARG 4835/4885PPARA 4715/4885
US-20180021448-A9 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 ATM 3020/4885PPARG 4835/4885PPARA 4715/4885
US-20170296663-A1 Conjugates of Cell Binding Molecules with Cytotoxic Agents CD4, CD2, CD47 ATM 3020/4885PPARG 4835/4885PPARA 4715/4885
US-11834406-B2 Conjugates of cell binding molecules with cytotoxic agents CD4, CD2, CD47 ATM 3065/4885PPARG 4831/4885PPARA 4696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.