Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR known ✓ | P14679 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | G6PD | P11413 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IL2 | P60568 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbutin SCHEMBL13313589 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL435261 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4287194 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL285242 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL15483307 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4288562 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4285717 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL36351 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13971238 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL18175043 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017093698-A1 | BIPHOTONIC PHOTOSENSITIZING DENDRIMERS, MANUFACTURING METHOD AND USES | UNIVERSITE DE RENNES 1 (FR) | 2017-06-08 | — | — | WO | disclosed |