Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR known ✓ | P14679 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | G6PD | P11413 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IL2 | P60568 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbutin SCHEMBL13313589 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4289558 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL15481351 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL285242 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13956277 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL18175043 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL36352 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL5438300 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL12998301 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13054606 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1322 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116162640-B | Escherichia coli Rosetta strain and application thereof in catalytic synthesis of alpha-arbutin | Tichuang Biotechnology (Guangzhou) Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122075357-A | Composition with whitening and anti-wrinkle functions and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121271827-B | Sucrose phosphorylase mutant and application thereof in synthesis of alpha-arbutin | 山东三元生物科技股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122031311-A | Composition containing ganoderma sinensis fermentation filtrate and application of composition in skin repair and whitening | 广东圆度生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| WO-2025229086-A1 | ADHESIVE COSMETIC COMPOUNDS AND USES THEREOF | SKINOSIVE (FR) | 2025-11-06 | — | — | WO | claimed |
| US-20250332225-A1 | Injectable Neutral pH Collagen-Based Composition For Mesotherapy | SHANGHAI QISHENG BIOLOGICAL PREPARATION CO LTD (CN) | 2025-10-30 | — | — | US | claimed |
| CN-120189376-A | Whitening essence | 开平牵牛生物科技有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-120118734-A | Alpha-arbutin enzyme catalytic synthesis equipment and synthesis process thereof | 安徽瑞邦生物科技有限公司 | 2025-06-10 | — | — | CN | claimed |
| CN-120078694-A | Whitening and elastic essence and preparation method thereof | 开平牵牛生物科技有限公司 | 2025-06-03 | — | — | CN | claimed |
| CN-119709705-B | Alpha-glucosidase mutant and application thereof in synthesis of alpha-arbutin | 云合(天津)生物技术有限公司 | 2025-05-30 | — | — | CN | claimed |
| US-20090263339-A1 | AGENT FOR EXTERNAL APPLICATION TO THE SKIN | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKY (JP) | 2009-10-22 | — | — | US | claimed |
| EP-1894558-A1 | AGENT FOR EXTERNAL APPLICATION TO THE SKIN | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2008-03-05 | — | — | EP | claimed |
| EP-1289489-B1 | TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE | PENTAPHARM LTD (CH) | 2007-12-05 | — | — | EP | claimed |
| EP-1859835-A2 | Topical agent for dermatological use containing 4-hydroxyphenyl-alpha-D-glucopyranoside | PENTAPHARM Ltd. (CH) | 2007-11-28 | — | — | EP | claimed |
| CN-1635996-A | Topical skin preparation containing 4-hydroxyphenyl-alpha-D-glucopyranoside | PENTAPHARM LTD (CH) | 2005-07-06 | — | — | CN | claimed |
| US-20030198610-A1 | Topical agent for dermatological use | DSM IP ASSETS B.V. (NL) | 2003-10-23 | — | — | US | claimed |
| US-20030143251-A1 | Skin preparations for external use | EZAKI GLICO COMPANY LIMITED (JP) | 2003-07-31 | — | — | US | claimed |
| EP-1289489-A2 | TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE | PENTAPHARM Ltd. (CH) | 2003-03-12 | — | — | EP | claimed |
| EP-1260211-A1 | SKIN PREPARATIONS FOR EXTERNAL USE | PENTAPHARM Ltd. (CH) | 2002-11-27 | — | — | EP | claimed |
| WO-2001091715-A2 | TOPICAL AGENT FOR DERMATOLOGICAL USE CONTAINING 4-HYDROXYPHENYL-ALPHA-D-GLUCOPYRANOSIDE | PENTAPHARM LTD. (CH) | 2001-12-06 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030198610-A1 | Topical agent for dermatological use | GALE, UGGT1, UGDH | TYR 6/4885POLB 2460/4885KDM4E 611/4885 |
| US-20030143251-A1 | Skin preparations for external use | TYR, GAA, CUTA | TYR 1/4885POLB 419/4885KDM4E 2467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.