Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbutin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR known ✓ | P14679 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | G6PD | P11413 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | IL2 | P60568 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbutin SCHEMBL13313589 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL4289558 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL15481351 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13956277 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL18175043 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL36352 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL5438300 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL12998301 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL13054606 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT | |
| Arbutin SCHEMBL435261 | 1.00 | TYR (1.00) | TYRPOLBKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 236 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114425024-A | Stabilized compositions containing hydroquinone or derivatives thereof | 株式会社LG生活健康 | 2022-05-03 | — | — | CN | claimed |
| CN-111393492-B | Alkyne-alkene hydroquinone glucoside, preparation method thereof and application of alkyne-alkene hydroquinone glucoside in preparation of liver X receptor agonist | 中国科学院南海海洋研究所 | 2021-06-11 | — | — | CN | claimed |
| CN-111870555-A | Anti-aging repair essence and preparation process thereof | 江苏奥普莱医疗用品有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-111393492-A | Alkyne-alkene hydroquinone glucoside, preparation method thereof and application of alkyne-alkene hydroquinone glucoside in preparation of liver X receptor agonist | 中国科学院南海海洋研究所 | 2020-07-10 | — | — | CN | claimed |
| CN-1849390-A | High level production of arbutin in green plants and microbes | DU PONT (US) | 2006-10-18 | — | — | CN | claimed |
| US-7056742-B2 | High Level production of arbutin in green plants | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-06-06 | — | — | US | claimed |
| WO-2004113504-A2 | HIGH LEVEL PRODUCTION OF ARBUTIN IN GREEN PLANTS AND MICROBES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-12-29 | — | — | WO | claimed |
| US-20040261147-A1 | High level production of arbutin in green plants and microbes | UNIVERSITY OF NORTH TEXAS | 2004-12-23 | — | — | US | claimed |
| JP-9175987-A | — | — | None | — | — | JP | disclosed |
| JP-61225106-A | — | — | None | — | — | JP | disclosed |
| JP-7206632-A | — | — | None | — | — | JP | disclosed |
| JP-61225112-A | — | — | None | — | — | JP | disclosed |
| JP-6009366-A | — | — | None | — | — | JP | disclosed |
| JP-9077654-A | — | — | None | — | — | JP | disclosed |
| JP-H06107533-A | COSMETIC | POLA CHEM IND INC | 1994-04-19 | — | — | JP | disclosed |
| JP-H069366-A | EXTERNAL AGENT FOR SKIN | SHISEIDO CO LTD | 1994-01-18 | — | — | JP | disclosed |
| US-4764505-A | GLYCOSIDE OF HYDROQUINONE-SUPPRESSION OF SKIN IRRITATION | SHISEIDO COMPANY LTD. (JP) | 1988-08-16 | — | — | US | disclosed |
| JP-S61225106-A | DERMATIC AGENT FOR EXTERNAL USE | SHISEIDO CO LTD | 1986-10-06 | — | — | JP | disclosed |
| JP-S61225112-A | HAIR COSMETIC | SHISEIDO CO LTD | 1986-10-06 | — | — | JP | disclosed |
| JP-S61225114-A | DERMATIC AGENT FOR EXTERNAL USE | SHISEIDO CO LTD | 1986-10-06 | — | — | JP | disclosed |