Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20528677 | 0.77 | HDAC1 (0.44) | HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL27897967 | 0.76 | CASP3 (0.62) | HDAC6HDAC1HDAC4HDAC8HDAC5 | |
| SCHEMBL17315868 | 0.76 | HDAC6 (0.47) | HDAC6HDAC1HDAC4HDAC8HDAC5 | |
| SCHEMBL19464122 | 0.72 | HDAC1 (0.54) | HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL29362802 | 0.72 | HDAC1 (0.54) | HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL19124280 | 0.72 | HDAC6 (0.47) | HDAC6HDAC1HDAC4HDAC8HDAC5 | |
| SCHEMBL18795777 | 0.72 | HDAC4 (0.54) | HDAC6HDAC1HDAC4HDAC8 | |
| SCHEMBL10552640 | 0.72 | HDAC4 (0.62) | HDAC6HDAC1HDAC4HDAC8HDAC5 | |
| SCHEMBL2224867 | 0.72 | NPC1 (0.63) | HDAC6HDAC1HDAC4HDAC8HDAC5 | |
| SCHEMBL29242012 | 0.72 | HDAC6 (0.46) | HDAC6HDAC1HDAC4HDAC8HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3400223-A1 | MICROBIOCIDAL OXADIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2018-11-14 | — | — | EP | disclosed |
| EP-3383179-A1 | MICROBIOCIDAL OXADIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2018-10-10 | — | — | EP | disclosed |
| WO-2018177880-A1 | FUNGICIDAL COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2018-10-04 | — | — | WO | disclosed |
| WO-2017118689-A1 | MICROBIOCIDAL OXADIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017093348-A1 | MICROBIOCIDAL OXADIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-06-08 | — | — | WO | disclosed |